Date of Award

5-2026

Document Type

Thesis

Degree Name

Master of Arts in Psychological Science

Department

Psychology

First Reader/Committee Chair

Amodeo, Leslie

Abstract

The postpartum period is characterized by profound physiological and psychological changes, including disruptions in sleep and activity patterns, which may contribute to the onset of postpartum depression. If left untreated, postpartum depression can result in long-term consequences, including cognitive impairments, emotional dysregulation, impaired maternal-infant attachment, and the onset of sleep-related disorders. Selective serotonin reuptake inhibitor (SSRI), escitalopram, is prescribed for the treatment of postpartum depression due to its efficacy, favorable safety profile, and relatively low cost. While escitalopram is considered an effective treatment for depression and anxiety, far less is known about its impact on maternal behaviors during the postpartum period. This study aims to (1) characterize sleep/wake patterns and affective-like behaviors across the maternal stages, and (2) investigate the impact of escitalopram on maternal behaviors when administered during the postpartum period. To this end, nulliparous Long-Evans female rats were administered escitalopram 10 mg/kg or control (IP) for 10 consecutive days during the postpartum phase (P2-11). An array of behaviors was assessed before pregnancy (baseline), at gestation days 7 and 14, and postpartum days 2, 10, and 15. Activity levels were monitored over a 24-hour period using non-invasive activity tracking devices. Sucrose preference test, open field, and maternal-pup interactions were assessed. Results suggest that rest/wake patterns and affective-like behaviors changed across gestation and postpartum periods. In assessing preconception compared to pregnancy, activity during the dark period became more fragmented. Time spent in the center of the open field decreased from preconception to the postpartum period. Escitalopram treated dams demonstrate a significant reduction in the number of rest episodes, more anxiety-like behavior in the open field, and an increase in pup interaction early in the postpartum period compared to controls.

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