Burden of Hospital Acquired Infection Among HIV Patients

SMSU Event Center BC

Objective: Human immunodeficiency virus (HIV) infection remains a public health issue, especially among vulnerable populations. In recent years, coinfection with HIV have emerged as a novel threat to morbidity and mortality though little evidence exists on the burden of hospital-acquired infections (HAIs) among HIV patients. In this study, we utilized the Nationwide Inpatient Sample (NIS) to assess the burden of HAIs among such patients. Methods: Survey weighted data from NIS were assessed to determine the prevalence Natural Sciences of clostridium difficile (CDI) and methicillin-resistant staphylococcus aureus (MRSA) and the burden of such co-infection among patient and hospital outcomes (in hospital mortality, length of stay, and total charges). Results: Prevalence of CDI and MRSA were noted as 2.88 and 3.12 per 1,000, respectively, among those with HIV, with higher rates reported among middle-aged adults (46%), males (68%), Blacks (56%), and those on Medicaid (42%). Incidence rate ratio (IRR) of length of stay among HIV patients with CDI and MRSA were 2.02 and 1.43 respectively, while odds of in-hospital mortality was 74% higher among CDI discharges and 34% higher MRSA discharges. Finally, total charges for HIV increased by 56% and 42% upon presence of CDI and MRSA, respectively. Conclusion: With increasing rates of globalization coupled with change in the weather matter, emerging infectious diseases have become prevalent. CDI and MRSA are two such examples, and the results of our study demonstrate that such coinfection with HIV posit a significant healthcare burden with increased length of stay, in-hospital mortality, and total charges.