Presentation Title
Exposure To Social Defeat During Adolescence Results In Depressive-Like Behaviors In Male C57bl/6 Mice
Presentation Type
Oral Presentation
College
College of Social and Behavioral Sciences
Major
Biology
Psychology
Session Number
3
Location
RM 211
Juror Names
Moderator: Dr. Christopher Gentry
Start Date
5-21-2015 4:20 PM
End Date
5-21-2015 4:40 PM
Abstract
Stress exposure is highly correlated with the development of mood-related psychopathologies, such as major depressive disorder (MDD). Since the first episodes of MDD often emerge during adolescence, we sought to investigate whether exposure to social defeat – a model commonly used to examine depressive-like behaviors in adult animals – would result in decreased social interaction and increased sensitivity to inescapable stressors during adolescence. To do this, we exposed adolescent male c57BL/6 mice to 10 consecutive days of social defeat (postnatal days [PD] 35-44). Twenty-four hours following the last defeat episode (PD45), separate cohorts of mice were tested on the social interaction and forced swim tests. When compared to non-stressed controls, defeated mice displayed depressive-like behaviors as inferred from decreased social interaction, as well as increased total immobility in the forced swim test. When taken together, our findings indicate that exposure to social defeat during adolescence will yield depressive-like behavioral outcomes, which suggests that this model can be used to investigate stress-induced mood-related disorders in younger populations.
Exposure To Social Defeat During Adolescence Results In Depressive-Like Behaviors In Male C57bl/6 Mice
RM 211
Stress exposure is highly correlated with the development of mood-related psychopathologies, such as major depressive disorder (MDD). Since the first episodes of MDD often emerge during adolescence, we sought to investigate whether exposure to social defeat – a model commonly used to examine depressive-like behaviors in adult animals – would result in decreased social interaction and increased sensitivity to inescapable stressors during adolescence. To do this, we exposed adolescent male c57BL/6 mice to 10 consecutive days of social defeat (postnatal days [PD] 35-44). Twenty-four hours following the last defeat episode (PD45), separate cohorts of mice were tested on the social interaction and forced swim tests. When compared to non-stressed controls, defeated mice displayed depressive-like behaviors as inferred from decreased social interaction, as well as increased total immobility in the forced swim test. When taken together, our findings indicate that exposure to social defeat during adolescence will yield depressive-like behavioral outcomes, which suggests that this model can be used to investigate stress-induced mood-related disorders in younger populations.
