Date of Award

2012

Document Type

Thesis

Degree Name

Master of Science in Biology

Department

Biology

First Advisor

Middleton, Kevin

Second Advisor

Chao, Michael

Third Advisor

Owerkowicz, Tomasz

Abstract

The studies presented here evaluate the effects of exercise and genetics on biomechanically important traits and the skeletal system's role in maintaining proper metabolic health. The goal of the project presented here is to further our understanding of the leptin-bone-insulin pathway and relevant changes that may occur in this pathway as a result of exercise. Cross-sectional analyses of HR mice and control mice allowed or denied wheel access for 10 weeks, revealed significant differences in biomechanical properties.

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