Date of Award
Master of Science in Biology
The purpose of this research was to investigate the Nucleoprotein (NP) RNA dependent RNA polymerase (RdRP) interaction by identifying and characterizing a NP mutant which maintains RNA binding but is unable to interact with the viral polymerase complex. Influenza poses a threat to human health and is a burden on the global economy. Influenza is caused by influenza virus which contains a segmented RNA genome, resulting in rapid evolution and emergence of new influenza subtypes which lead to pandemics.
Sanchez, Abel, "Influenza nucleoprotein interactions as potential antiviral targets" (2011). Theses Digitization Project. 3956.