Author

Abel Sanchez

Date of Award

2011

Document Type

Thesis

Degree Name

Master of Science in Biology

Department

Biology

First Advisor

Newcomb, Laura

Second Advisor

Chao, Michael

Third Advisor

Orwin, Paul

Abstract

The purpose of this research was to investigate the Nucleoprotein (NP) RNA dependent RNA polymerase (RdRP) interaction by identifying and characterizing a NP mutant which maintains RNA binding but is unable to interact with the viral polymerase complex. Influenza poses a threat to human health and is a burden on the global economy. Influenza is caused by influenza virus which contains a segmented RNA genome, resulting in rapid evolution and emergence of new influenza subtypes which lead to pandemics.

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