Date of Award
Master of Science in Psychology
The purpose of this project is to determine how early methylphenidate exposure alters opioid receptor functioning in adulthood. To this end, we will administer selective monoamine transporter inhibitors for dopamine and norepinephrine (GBR-12904 and atomoxetine) during preweanling period and assess opioid function in adult rats by testing morphine-induced antinociception using the hot-plate and tail-flick tasks. In order to assess the effects of methylphenidate use on brain functions during development, investigations have been conducted in rats using ages roughly analogous to early and late childhood.
Valentine, Joseph Marco, "Preweanling exposure to selective catecholamine transporter inhibitors differentially effects morphine-induced antinociception in adulthood" (2013). Theses Digitization Project. 4228.