Biconditional discrimination learning in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis
Date of Award
Master of Science in Psychology
Butt, Allen E.
McDougall, Sanders A.
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.
Kitto, Michael Ryan, "Biconditional discrimination learning in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis" (2006). Theses Digitization Project. 3002.