Date of Award

2011

Document Type

Thesis

Degree Name

Master of Science in Psychology

Department

Psychology

First Advisor

Butt, Allen

Second Advisor

Crawford, Cynthia

Third Advisor

Chien, Yuchin

Abstract

The nucleus basalis magnocellularis (NBM) sends cholinergic projections to the neocortex. While NBM activation of the neocortex regulates attention and contributes to memory formation, the mechanisms controlling NBM activity during attention-dependent learning are not well understood. The current experiment tested the hypothesis that the mPFC is critically involved in modulating NBM activity during attention-dependent learning in rats. A total of 80 male Long-Evans rats were purchased from a commerical research animal vendor. Rats were randomly assigned to one of four controlled groups. The procedures were done by an animal technician and veterinarian in the CSUSB Social and Behavioral Science vivarium at California State University, San Bernardino.

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