Date of Award
2010
Document Type
Thesis
Degree Name
Master of Science in Psychology
Department
Psychology
First Advisor
Crawford, Cynthia
Second Advisor
McDougall, Sanders
Third Advisor
Riggs, Matt
Abstract
Methylphenidate is the preferred treatment for attention-deficit hyperactivity disorder in preschool-aged children, even though few human studies have assessed the long-term consequences of early methyphenidate use. In rats, exposure to methylphenidate during a developmental period that approximates early childhood increases morphine-induced antinociception in adulthood. However, because morphine activates three distinct opioid receptors it is unknown which receptor is resonsible for this methylphenidate effect. The purpose of the present study was to assess the long-term effects of early methylphenidate exposure on DAMGO- and U50, 488-induced antinociception, a mu-opioid and kappa-opioid selective agonist.
Recommended Citation
Herbert, Matthew Scott, "Consequences of early methylphenidate exposure on opioid system functioning in adult rats" (2010). Theses Digitization Project. 3854.
https://scholarworks.lib.csusb.edu/etd-project/3854
