Date of Award
Master of Science in Biology
The design of the proposed study was to administer R-FB to 72-day old Min/+ mice for up to 42 days. In order to capture the process of tumor reduction, animals were necropsied at various time points. At each time point animals were evaluated for tumor loads and presence of apoptotic cells along the small intestine. Studies have shown that when R-flurbiprofen (R-FB) is administered in the Min/+ mouse model it can cause the prevention and regression on intestinal tumors.
Quiggle, David Douglas, "The effects of R-flurbiprofen in reducing tumors in a multiple intestinal neoplasia mouse model" (2001). Theses Digitization Project. 2009.